UT Defense – 30ct

Cranberries/Anthocran

Cranberry juice has been used historically as a remedy for urinary tract health. The mechanism of action of cranberry juice and its extracts is the inhibition of microbial binding to host cell surface membranes. In vitro studies have observed it to promote healthy microbial balance facilitated by proanthocyanidins PACs), which impact bacterial adherence and maintain the microbial health of the urinary tract. A recent meta-analysis of 10 clinical trials and 1,494 subjects, showed supplementation of cranberry-containing products supported urinary tract health and urine flow, in women and children, showing greater benefit for cranberry users by 38%. A meta-analysis of the results of four randomized controlled clinical trials, found prophylactic use of cranberry significantly supported urinary tract health over a 12-month period, compared with placebo. In a 2015 clinical trial comparing the use of Anthocran^® plus lifestyle intervention to only lifestyle intervention, there was shown to be a 73.3% reduction in frequency of urinary tract challenges of the Anthocran^® group compared to the lifestyle control group, which saw a 15.4% decrease. In addition, 31.8% of the Anthocran^® subjects were symptom-free, and none of the control group were symptom-free. It was also noted there was a decrease in any urinary challenge duration from those that only received lifestyle intervention.

Hibiscus sabdariffa

H. sabdariffa extracts have long been used in herbal teas and for urinary tract support. H. sabdariffa calyx in a 10:1 extract (Ellirose™ extract) includes compounds that promote microbial balance, and prevent bacteria from adhering to the bladder wall, including substantial amounts of flavonoids, sambubiocides, anthocyanidins, proanthocyanidins and chlorogenic acids. In addition, other ingredients such as polysaccharides and a high concentration of simple organic acids provide urinary tract support. An in vitro study on Hibiscus calyx and protocatechuic acid has shown its ability to promote microbial balance, mediated by protocatechuic acid content and a six-month, double-blind, placebo controlled study, found 200 mg of H. sabdariffa extract taken once a day, significantly promoted urinary tract health by 77%.

Dandelion Leaf Extract

Dandelion leaf has a history of use in various preparations including infusions, extracts, and fresh expressed juice for improving urinary tract function. A clinical study of 17 participants given an extract of T. officinale fresh leaf, found it contains the ability to increase the frequency and excretion ratio of fluids in these healthy subjects.